Which type of neuromuscular disease is characterized by leading muscle weakness and fatigue?

Myasthenia gravis is a neuromuscular disease characterized primarily by muscle weakness and fatigue, particularly with exertion. It results from an autoimmune response where the body's immune system mistakenly attacks acetylcholine receptors at the neuromuscular junction. This impairs communication between the nerves and muscles, leading to symptoms that typically worsen with activity and improve with rest.

Patients often experience ocular symptoms, such as drooping eyelids or double vision, and may encounter difficulties with facial expressions, swallowing, and other muscle-controlled functions. The hallmark feature of myasthenia gravis is that the weakness fluctuates; individuals may feel stronger after resting. This characteristic pattern is crucial to differentiating it from other neuromuscular disorders that may present with more constant weakness.